So which do you think are the most complicated settings in terms of strategy? In what game you filled you understand nothing about what is going on? In what game settings you beleive a more capable player (in terms of pure strategy) will just crush you and luck is not going to save you?
I vote
Hive, quadruples, trench, sequential the basic settings followed by
automatic, no spoil, chained, sunny (or even fog for the most crazy people)